FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to ANHYDROUS crystalline form of (R)-(-)-N-[4,4-di-(3-methylthiene-2-yl)-but-3-enyl] -nipecotic acid hydrochloride free of bound organic solvent (I) that is nonhygroscopic and thermostable under normal conditions of storage. Compound (I) inhibits absorption of gamma-aminobutyric acid and can be used in medicine for treatment of epileptic patients. EFFECT: improved properties of compound, enhanced effectiveness of treatment. 5 cl
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1995 |
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1996 |
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- Nel'Sen Flemming Ehl'Melund
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1990 |
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- Preben Khoulberg Olesen[Dk]
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| METHOD OF TREATMENT OF PSYCHOTIC DISORDERS |
1994 |
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| STEROIDS, METHOD OF REGULATION OF MEIOSIS |
1996 |
- Frederik Khristian Grenvall'
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1997 |
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- Polivka Zdenek
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1997 |
- Nil'Sen Flemming Ehl'Melunn
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|
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| 2-AMINO-N-{(1R)-2-[(3R)-3-BENZYL-3-(N,N',N'-TRIMETHYLHYDRAZINOCARBONYL)PIPERIDINE-1-YL]-1-(1H-INDOL-3-YLMETHYL)-2-OXOETHYL}-2-METHYLPROPIONAMIDE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR STIMULATION OF GROWTH HORMONE RELEASE FROM MAMMAL HYPOPHYSIS |
2000 |
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