3-(1,2,5-OXADIAZOLE-3-YL)- OR 3-(1,2,5-THIADIAZOLE-3-YL)-1,2,5,6-TETRAHYDROPYRIDINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, AND PHARMACEUTICAL COMPOSITION SHOWING MUSCARINIC, CHOLINERGIC, RECEPTOR AGONISTIC ACTIVITY Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: 3-(1,2,5-oxadiazole-3-yl) or 3-(1,2,5-thiadiazole-3-yl)-1,2,5,6-tetrahydropyridine derivatives of the formula where Z oxygen or sulfur; R hydrogen or C_1-3-alkyl; at Z oxygen R₁ is halogen, amino-group, acetylamino-group or -O-R₂, where R₂-C_4-6-alkyl or C_4-6-alkynyl; at Z sulfur R₁- means halogen, C_1-8-alkyl, C₆-alkenyl with direct chain, cyclopropylmethyl, benzylhydroxy-group, morpholino-, 4-methylpiperidine- or 4-hexylamino-group, or -O-R₂,-group where R₂- linear or branched C_1-8-alkyl, C_3-6-alkenyl, C_3-6-alkynyl, cyclopropylmethyl or -R₃-O-R₄- or -R₃-O-R₄-O-R₅,-group where each R₃-R₅ means C_1-4-alkyl; or R₁ means S-R₂,-group where R₂ linear C_2-8-alkyl, or their pharmaceutically acceptable salts, and pharmaceutical composition. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 2 tbl