DERIVATIVES OF [1,2,4]-TRIAZOLO-[4,3-A]-QUINOXALINONE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITION OF AMPA- -RECEPTORS Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention proposes derivatives of [1,2,4]-triazolo-[4,3-a] of the general formula (I) where R¹ means linear or branched C_1-6-alkyl, substituted COX' or POX'X'' where X' and X'' means independently hydroxyl- or alkoxy-group; R⁶ and R⁹ mean hydrogen atom; R⁷ means CF₃ and R⁸ means imidazolyl, piperidino- or morpholino-group being their rings are optionally substituted with one or two substituents taken among phenyl and C_1-6-alkyl, or their pharmaceutically acceptable salts. Compounds of the formula (I) show antagonistic activity with respect to AMPA-receptors and are useful for treatment of patients with symptoms of hyperactivity of exciting neuromediators. Invention proposes also method of synthesis of compounds of the formula (I), pharmaceutical composition based on said and method of inhibition of AMPA-receptors activity. EFFECT: improved method of synthesis, valuable pharmacological properties. 8 cl, 1 tbl, 13 ex