STEROIDS, METHOD OF REGULATION OF MEIOSIS Russian patent published in 2002 - IPC

FIELD: organic chemistry, steroids, biology. SUBSTANCE: invention relates to steroids of sterol order of the general formula (I) where R¹ and R² are taken independently among the group including hydrogen atom and unbranched or branched C₁-C₆-alkyl; R³ is taken among the group including hydrogen atom, methylene, hydroxy-group, oxo-group, =NOR²⁶ where R²⁶ means hydrogen atom and hydroxy-group and C₁-C₄-alkyl bound with the same carbon atom of sterol skeleton; or R³ in common with R⁹ or R¹⁴ mean additional bond between carbon atoms with that R³ and R⁹ or R¹⁴ are bound; R⁴ is taken among the group including hydrogen atom and oxo- group; or R⁴ in common with R¹³ mean additional bond between carbon atoms with that R⁴ and R¹³ are bound; R⁵ is taken among the group including hydrogen atom and hydroxy-group; or R⁵ in common with R⁶ mean additional bond between carbon atoms with that R⁵ and R⁶ are bound; R⁶ means hydrogen atom; or R⁶ in common with R⁵ mean additional bond between carbon atoms with that R⁶ and R⁵ or R¹⁴ are bound; R⁹ means hydrogen atom; or R⁹ in common with R³ or R¹⁰ mean additional bond between carbon atoms with that R⁹ and R³ or R¹⁰ are bound; R¹⁰ means hydrogen atom; or R¹⁰ in common with R⁹ mean additional bond between carbon atoms with that R¹⁰ and R⁹ are bound; R¹¹ is taken among the group including hydroxy-, acyloxy-, oxo-group, =NOR²⁸ where R²⁸ means hydrogen atom, halogen atom; or R¹¹ in common with R¹² mean additional bond between carbon atoms with that R¹¹ and R¹² are bound; R¹² means hydrogen atom; or R¹² in common with R¹¹ mean additional bond between carbon atoms with that R¹² and R¹¹ are bound; R¹³ means hydrogen atom; or R¹³ in common with R⁴ or R¹⁴ mean additional bond between carbon atoms with that R¹³ and R⁴ or R¹⁴ are bound; R¹⁴ means hydrogen atom; or R¹⁴ in common with R³,R⁶ or R¹³ means additional bond between carbon atoms with that R¹⁴ and R³ or R⁶ or R¹³ are bound; R¹⁵ means hydrogen atom; R¹⁶ is taken among the group including hydrogen atom, hydroxy-group, oxo-group; or R¹⁶ in common with R¹⁷ mean additional bond between carbon atoms with that R¹⁶ and R¹⁷ are bound; R¹⁷ means hydrogen atom or hydroxygroup; or R¹⁷ in common with R¹⁶ mean additional bond between carbon atoms with that R¹⁷ and R¹⁶ are bound; R¹⁸ and R¹⁹ mean hydrogen atom; R²⁵ is taken among the group including hydrogen atom and C₁-C₄-alkyl; A means carbon atom or nitrogen atom; when A means carbon atom then R⁷ is taken among the group including hydrogen atom, hydroxy- group and fluorine atom; R⁸ is taken among the group including hydrogen atom, C₁-C₄-alkyl, methylene and halogen atom; or R⁷ in common with R⁸ mean additional bond between carbon atoms with that R⁷ and R⁸ are bound; R²⁰ means C₁-C₄-alkyl; and R²¹ is taken among the group including C₁-C₄-alkyl, C₁-C₄-hydroxyalkyl, C₁-C₄- halogenalkyl comprising up to three halogen atoms; when A means nitrogen atom then R⁷ means unshared electron pair; R⁸ is taken among the group including hydrogen atom and oxo-group; R²⁰ and R²¹ mean C₁-C₄-alkyl under condition that compound of the general formula (I) has no any cumulated double bonds and with additional condition that compound is not one of the known cholestene compounds. Compounds (I) can be used for regulation of meiosis in germinal cell of mammal. EFFECT: valuable biological properties of steroids. 67 cl, 2 tbl, 40 ex