DERIVATIVES OF DIBENZO[D,G][1,3]DIOXOCINE AND DIBENZO[D,G]- [1,3,6]DIOXAZOCINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT OF NEUROGENIC INFLAMMATION, NEUROPATHY AND RHEUMATIC ARTHRITIS Russian patent published in 2002 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel compounds of the formula (I): where R¹ and R² mean hydrogen, halogen atom independently; R³ means hydrogen atom; A means C_1-3-alkylene; Y means where the underlined atom takes part in ring system; Z is taken among: where R¹² means hydrogen atom; R¹³ means hydrogen atom; R¹⁴ means -(CH₂)_tCOR¹⁵ where n = 0 or 1 and where R¹⁵ means -OH, C_1-6-alkoxy-group; is optionally a single or double bond. Invention relates to also their pharmaceutically acceptable salts and method of their synthesis, pharmaceutical composition based on thereof and methods of treatment of patients with neurogenic inflammation, neuropathy and rheumatic arthritis. New compounds are used in therapy of diseases where C- fibers play pathophysiological function causing neurogenic pain or inflammation. EFFECT: new compounds indicated above, improved method of synthesis, valuable medicinal properties. 17 cl, 1 tbl