FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to 1,4-disubstituted piperazines of the general formula (I) 
, method of their synthesis, composition comprising thereof and their use for clinical therapy of morbid states, enhanced pain sensitivity and/or inflammatory states where C-fibers take part pathophysiological role causing neurogenic pain or inflammation. EFFECT: improved method of synthesis and treatment, valuable medicinal properties. 34 cl, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND PHARMACEUTICAL COMPOSITION | 1997 |
|
RU2186769C2 |
| N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INHIBITION OF NEUROGENIC INFLAMMATION | 1995 |
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| DERIVATIVES OF DIBENZO[D,G][1,3]DIOXOCINE AND DIBENZO[D,G]- [1,3,6]DIOXAZOCINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT OF NEUROGENIC INFLAMMATION, NEUROPATHY AND RHEUMATIC ARTHRITIS | 1996 |
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| 0 |
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SU348002A1 | |
| DERIVATIVES OF [1,2,4]-TRIAZOLO-[4,3-A]-QUINOXALINONE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITION OF AMPA- -RECEPTORS | 1995 |
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| 0 |
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| CONDENSED DERIVATIVE OF 1,2,4-THIADIAZINE, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREPARING MEDICINE | 1998 |
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| COMPOUNDS AND THEIR USING FOR DECREASING HORMONE-SENSITIVE LIPASE ACTIVITY | 2002 |
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