N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND THEIR ESTERS, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION, METHOD FOR INHIBITION OF NEUROGENOUS PAIN, INFLAMMATION AND BLOOD GLUCOSE LEVEL IN PATIENT Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine.

SUBSTANCE: invention describes N-substituted azaheterocyclic carboxylic acids and their esters of the formula (I):

wherein R¹ and R² represent independently hydrogen, halogen atom, NR⁶R⁷ or (C₁-C₆)-alkyl; Y represents >N-CH₂ or >C=CH₂- wherein only underlined atom is a component of the ring system; X represents -O-, -S-, -CH₂CH₂- wherein R⁶ and R⁷ represent independently (C₁-C₆)-alkyl; r = 1, 2 or 3; Z represents heterocycle taken among formulas (a), (b), (c), (d), (f), (k), (g) and (j) given in the invention claim. Also, invention relates to a method for their preparing and pharmaceutical composition based on compounds of the formula (I). Invention describes a method for inhibition of neurogenous pain, inflammation and blood glucose level increase to patient by administration to patient the effective dose of compound of the formula (I). Compounds of the formula (I) elicit ability to inhibit the neurogenous pain and blood glucose enhanced level.

EFFECT: improved preparing method, valuable medicinal properties of compounds.

13 cl, 1 tbl, 30 ex