FIELD: medicine. SUBSTANCE: method involves selecting donor serum samples by applying immunoenzyme analysis and PCR (polymerizno-chain reaction) for detecting hepatitis B virus DNA and anti-HBS antibodies. Diluting solution is prepared on the base of selected sera. HBSAg standard is diluted with the diluting solution. Solution thermodegradation and stabilization test is carried out. EFFECT: improved vaccine quality control; constant virus protein concentration on reference palette within long time period. 5 cl, 1 dwg, 2 tbl
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