MASTER-PANELS OF SERA COMPRISING AND NOT COMPRISING HBsAg AND METHOD FOR ITS PREPARING Russian patent published in 2008 - IPC G01N33/96 

FIELD: biotechnology, immunology, vaccines.

SUBSTANCE: invention relates to Master-panel used for assay of hepatitis B. Invention proposes Master-panel of lyophilized sera comprising and not comprising HBsAg wherein the positive part of Master-panel comprises plasma samples obtained from patients suffering from hepatitis B and consists of three blocks: block 1 comprises sera of A & D genotypes of different subtypes HBsAg (ayw2, ayw3, adw4 and adw2), block 2 comprises positively attested sera diluted to mean and low concentrations (in the range from 1.5 IU/ml to 0.05 IU/ml), block 3 comprises sera showing OD values near or below OD_cr and positive by PCR method or having high level of aminotransferases activity; negative part of panel comprises plasma samples obtained from donors, persons from risk groups and vaccinates persons. Master-panel must store at temperature 2-6^°C and diluted sera for panel are stored at temperature 2-6^°C for one month and at temperature -24^°C for 6 months. Master-panel provides standardizing sera used in carrying out analysis for hepatitis B.

EFFECT: valuable medicinal and analytical properties of sera.

4 cl, 1 tbl, 2 ex