METHOD FOR IN VITRO DETERMINING OSTEOINTEGRATION PROPERTIES OF MATERIALS USEABLE FOR MANUFACTURING BONE IMPLANTS Russian patent published in 2002 - IPC

FIELD: medicine. SUBSTANCE: method involves culturing test-object like occipital or frontal bone fragment deprived of periosteum newborn rat aged less than 1 week. Tested material sample is placed on the fragment. Ratio of osteoblast-like cells- inhabited surface area and upper sample surface area is calculated at the fourth day and the thickness of collagen layer deposited by cells at the fourteenth day of culturing is determined for evaluating biological compatibility of the material. EFFECT: high accuracy in determining qualitative and quantitative values for predicting outlook on the further material testing. 1 tbl