FIELD: molecular biotechnology, medicine. SUBSTANCE: invention presents a reconstructed human anti-HM 1.24 antibody where C-site of H- and L-chain and V-site of H- and L-chain comprise human FR and CDR is prepared from anti-HM 1.24 monoclonal antibody and CDR shows low antigenicity. Reconstructed human anti-HM 1.24 antibody is prepared by transformation of Cell-host with expressing vector that comprises DNA encoding antibody. Human anti-HM 1.24 antibody is used as an active component for treatment of myeloma. EFFECT: improved method of preparing, valuable antitumor property. 17 cl, 40 dwg, 6 tbl
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