H- AND L-CHAINS OF MONOCLONAL ANTIBODY PM-1 (MONAT) TO HUMAN IL-6R RECEPTOR AND THEIR V-REGION, MODIFIED MONAT, ITS H- AND L-CHAINS AND THEIR V-REGIONS, CDR-SEQUENCE, DNA-SEQUENCE Russian patent published in 1999 - IPC

FIELD: biotechnology, immunology. SUBSTANCE: invention relates to the V-region of L-chain of murine monoclonal antibodies to human IL-6R and H-chain of V-region of murine monoclonal antibodies to human IL-6R. Also, modified antibodies to human IL-6R, DNA-sequence encoding the above indicated antibodies or their fragments are given. Antibodies to human IL-6R receptors can be used as a therapeutic agent for treatment of patients with myeloma. EFFECT: antibodies as the medicinal preparation. 24 cl, 24 dwg, 9 tbl, 17 ex