SYNTHETIC PEPTIDES USING IN BIOLOGICAL TESTS FOR DETECTION INFECTIONS CAUSED BY VIRUSES HIV-1 OF GROUP 0 Russian patent published in 2002 - IPC

FIELD: virology, peptides. SUBSTANCE: invention relates to novel synthetic peptides of monomeric type with 13-33 amino acids or dimeric type with 26-66 amino acids of linear form or form cyclizated by intercysteine disulfide bridges and corresponding to the formula (I): Δ-Z-Trp-Gly-Cys-Θ-Cys-Tyr-Thr-Ser-Ω where: Δ means biotinyl, biocitinyl, hydrogen atom, acetyl-(CH₃CO-, aliphatic chain that can comprise one or some thiol, aldehyde or amine functions; aliphatic chain presents mainly alkyl chain with 1-6 carbon atoms or alkenyl chain with 2-6 carbon atoms or aminoalkylcarbonyl chain with 2-6 carbon atoms; Z means a peptide sequence of one of formulas: -Ξ₁-Ser-Ξ₂- (11), -Ξ₁-Gln-Ξ₂- (Y), -Ξ₁-Asn-Ξ₂- (YIII) where Ξ₁ means a peptide sequence with 2-9 amino acids; Ξ₂ means a peptide sequence with 0-5 amino acids; Θ means a peptide sequence of the formula (XI): -(AA₁)-(AA₂)-(AA₃)-(AA₄)-(AA₅)- (XI) where (AA₁) is lysine or arginine residue; (AA₂) is glycine residue; (AA₃) is lysine or arginine residue; (AA₄) is leucine or alanine residue; (AA₅) is valine residue under condition that -(AA₁),(AA₂),(AA₃),(AA₄),(AA₅) never form together peptide sequences -Lys-Gly-Lys-Leu-Ile- and -Lys-Gly-Lys-Leu-Val-; Ω means fixed on the group -CO of serine means: hydroxyl, peptide sequence of the formula (XII): -Val--Σ-Ψ, where Σ means a sequence of the formula (XIII): -(AA₆)-Trp-Asn-(AA₇)-(AA₈) where (AA₆) is glutamine or arginine; (AA₇) means glutamine or serine; (AA₈) means threonine and where Ψ fixed on residue -CO-free amino acid (AA₈) means a group OH, peptide sequence of the formula (XV): -Val-Ψ where Ψ has a value indicated above. Invention relates to compositions used for detection of infection caused by HIV-1 of the group 0, methods of diagnosis of infections caused by HIV-1 of the group 0 and diagnostic set. Describing peptides using in compositions, methods of diagnosis of infections and in diagnostic sets ensure to obtain results exceeding those obtained by using the known peptides. EFFECT: new peptides indicated above, improved and valuable medicinal properties. 14 cl, 8 tbl, 4 ex