FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to polypeptide containing variant I-OnuI of homing-endonuclease (HE), as well as to polynucleotide encoding it. A vector containing the above-mentioned polynucleotide is also disclosed. The invention also relates to a cell containing the above-mentioned polypeptide or polynucleotide, as well as to a composition containing the above-mentioned cell.
EFFECT: invention is effective for adoptive cell therapy.
16 cl, 24 dwg, 2 tbl, 14 ex
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