FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to polypeptide for genetic editing of cell genome, containing an option of homing endonuclease (HE) I-OnuI, as well as to polynucleotide, iRNA and cDNA encoding it. A vector and a cell containing the above-mentioned polypeptide or polynucleotide are also disclosed. The invention also relates to a composition containing the above-mentioned cell, as well as to a method for editing human CBLB gene in a cell, providing the use of the above-mentioned polypeptide.
EFFECT: invention is effective for the treatment of cancer, including hematological malignant tumor.
21 cl, 13 dwg, 2 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| OPTIONS, COMPOSITIONS, AND METHODS FOR USE OF HOMING-ENDONUCLEASE PD-1 | 2017 |
|
RU2781083C2 |
| METHODS OF OBTAINING INDUSTRIAL PRODUCTS FROM PLANT LIPIDS | 2015 |
|
RU2743384C2 |
| IMPROVED IMMUNOGENICITY OF L2 HPV PEPTIDE | 2017 |
|
RU2743016C2 |
| MUC16-SPECIFIC CHIMERIC ANTIGEN RECEPTORS AND THEIR USE | 2019 |
|
RU2795198C2 |
| POLYPEPTIDES THAT ARE SOLUBLE RECEPTORS OF FIBROBLAST GROWTH FACTOR 3 (sFGFR3), AND WAYS OF THEIR APPLICATION | 2017 |
|
RU2751483C2 |
| NOVEL EUKARYOTIC CELLS AND METHODS FOR PREPARING THEM FOR RECOMBINANT EXPRESSION OF A PRODUCT OF INTEREST | 2014 |
|
RU2720525C2 |
| FUSION PROTEIN OF DCTN1 PROTEIN WITH RET PROTEIN | 2018 |
|
RU2813996C2 |
| CD3-BINDING DOMAIN | 2015 |
|
RU2742691C2 |
| AFRICAN SWINE FEVER VACCINE | 2020 |
|
RU2819672C2 |
| EXPRESSION OF NITROGENASE POLYPEPTIDES IN PLANT CELLS | 2018 |
|
RU2809244C2 |
