METHOD TO PREDICT USUAL MISCARRIAGE Russian patent published in 2002 - IPC

FIELD: medicine, obstetrics. SUBSTANCE: it is conducted the study of immunogenetic profile of peripheral blood leucocytes in a marital couple. Based upon the values of HLA-antigens of classes I, II a discriminant function F is determined by a formula: F (x) = 0.78*A1 + 0.74*A9 + 0.77*A11 + 1.71*A28 - 0.94*A29 - 0.95*B21 + 5.04*B39 - 1.54*B57 - 1.87*B65 - 0.22*Dr5 + 1.39*Dr7 - 0.83*MA9 + 0.56*MA10 - 1.12*MA28 + 1.73*MA29 - 0.74*MB5 + 0.56*MB7 + 0.71*MB8 + 1.11*MB12 + 1.62*MB14 - 0.65*MB27 - 0.61*MB53 - 0.83*MDr2 - 1.60*MDr3 - 0.51*MDr5 - 0.67*MDr7 - 0.46, where A1, A9, A11, A28, A29 - female locus genes A, MA9, MA10, MA28, MA29 - male locus genes A, B21, B39, B57, B65 - female locus genes B, MB5, MB7, MB8, MB12, MB14, MB27, MB53 - male locus genes B, Dr5, Dr7 - female locus genes Dr, MDr2, MDr3, MDr5, MDr7 - male locus genes Dr, N - "the norm", if F (x) > 0, P - "pathology", if F (x) <0. The function obtained provides sensitivity of determinant prediction rule of 79.4%, specificity of 81%, efficiency of 80.7%. EFFECT: higher accuracy in predicting usual miscarriage at pregravidic period. 3 ex