FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to novel derivatives of 1-methyl-5-chloropyrazole of the general formula (I) 
where R means CH2Cl,CF3,4-ClC6H4,3-NO2C6H4 that show an antibacterial activity. Also, invention proposes a method of synthesis of derivatives of 1-methyl-5-chloro- -pyrazole where R means 
by interaction of corresponding derivatives of 2,2-dichlorodivinyl ketone of the formula RC(O)CH=CCl2 where R has said values with dimethylhydrazine in their mole ratio = 1:2, respectively, in an organic solvent medium at the room temperature for 0.5-12 h. Derivatives of 1-methyl-5-chloropyrazole, among them and novel compounds, are synthesized for a single stage from available raw that are perspective biologically active substances and technically value products that can be used for development of medicinal preparations, dyes, insecticides. EFFECT: improved method of synthesis, valuable properties. 3 cl, 3 tbl, 11 ex
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Year |
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1993 |
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1995 |
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1990 |
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1995 |
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RU2114822C1 |
| METHOD OF PREPARING 2-(4-HYDROXYPHENYL)ETHANOL |
1998 |
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RU2151137C1 |
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1993 |
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RU2044739C1 |
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1998 |
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2009 |
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