BENZIMIDAZOLE DERIVATIVE AND AGENT SHOWING ANTAGONISTIC ACTIVITY AGAINST SUBSTANCE P AND ANTIHISTAMINIC ACTIVITY Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to a novel derivative of benzimidazole of the formula (I) where A means a single bond or C_1-2- alkylene group; R⁶ means hydrogen atom or C_1-4- alkyl group; B means C_2-3- alkylene group; X means oxygen atom; each of R¹ and R² means hydrogen atom; E means C_1-2 alkylene group; R³ means phenyl group (this phenyl group can be optionally substituted with halogen atom); each of R⁴ and R⁵ that do not dependent each of other means hydrogen atom or C_1-4- alkyl group; D means C_1-4- alkylene group and Ar means phenyl group (this phenyl group can be optionally substituted with halogen atom, C_1-4- alkyl group, C_1-4- alkoxy-group or trifluoromethyl group). Invention describes also an agent showing an antagonistic activity against substance P and an antihistaminic activity. Invention can be used in the field of chemistry and medicine. EFFECT: new compound indicated above, valuable medicinal properties. 6 cl, 4 tbl, 28 ex