FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing an optically active chromene oxide compound of formula 
or formula 
where R5, R6, R7, R8, R9, R10 and A are as described in the claim, and the absolute configuration of carbon atoms, denoted by *, denotes (R) or (S), which includes asymmetric epoxidation of a chromene compound of formula 
or formula 
with an oxidant in a solvent using optically active titanium complexes of formula 
formula 
formula 
and formula 
where R1, R2, R3 and R4 are defined in the claim, as a catalyst for asymmetric oxidation of the optically active chromene compound with high enantioselectivity and high chemical output.
EFFECT: efficient method of producing an optically active chromene oxide compound, which is an important intermediate compound used to produce a benzopyran compound, which is effective in treating arrhythmia.
18 cl, 26 ex
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