FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the new anti-inflammatory composition involving an active component and a pharmaceutically acceptable carrier or diluting agent. As an active component the composition has an effective amount of the compound of the formula (I) 
where Y means nitrogen atom or G-C where G is C1-6-alkylhydroxycarbonyl; X means possibly oxidized sulfur atom or the group -(CH2)q where q - a whole number 1-5; R is C1-C10-alkyl, phenyl or phenyl-C1-4-alkyl possibly substituted with halogen atom, hydroxyl or C1-6-alkoxycarbonyl or a heterocyclic group taken from the group involving aromatic heterocyclic group and saturated or unsaturated nonaromatic heterocyclic group being each group has at least one heteroatom as cycle-forming atom taken from oxygen, sulfur or nitrogen atom. Heterocyclic group involves cycle-forming carbon atom bound to X and it can be optionally substituted with C1-6-alkyl optionally substituted with halogen atom or hydroxyl, phenyl, phenyl-(C1-4)-alkyl, hydroxyl or oxo-group, C1-6-alkoxy-group or halogen atom or pyridyl; A - cycle and B - cycle and each can be independently substituted with from 1 to 3 similar or different substituents taken from the group involving halogen atom, optionally halogenated lower alkyl, C1-4-alkoxyl; adjacent to located substituents can be bound each with other and form the group of the formula: -O(CH2)n-O (n - a whole number from 1 to 3) forming a ring; k means 0 or 1. Synthesized compounds can form salt. Composition can be used for treatment of patients with arthritis. Invention describes also derivatives of quinoline and quinazoline and a method of their synthesis. EFFECT: improved method of synthesis, anti-inflammatory activity. 30 cl, 20 tbl, 99 ex
