NOVEL KETOBENZAMIDES Russian patent published in 2002 - IPC

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to novel ketobenzamides of the formula (I) where R¹ means phenyl, naphthyl, quinolyl, pyridyl, quinazolyl, quinoxalyl, benzothienyl, isoquinoline, tetrahydroisoquinoline or tetrahydroquinoline that can be both unsubstituted and substituted; R² means hydrogen atom or alkyl; R³ means alkyl that can carry phenyl ring; X means a bond, -(CH₂)_m, -(CH₂)_m-O-(CH₂)₀-, -(CH₂)_n-S-(CH₂)_m-, -CH= CH-, -CO-CH= CH-, ; R⁴ means groups OR⁶, NR⁷R⁸;; n is a number from 0 to 2. Compounds of the formula (I) show an inhibitory activity and therefore they are inhibitors of cysteine proteases, in part for example, calpain I and II and cathepsins B and L. EFFECT: valuable biochemical properties. 3 cl, 1 tbl, 41 ex