DERIVATIVES OF PIPERIDINE KETOCARBOXYLIC ACID Russian patent published in 2002 - IPC

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to novel derivatives of piperidine ketocarboxylic acid of the formula (I) where R¹ is COR⁴ or SO₂R⁴; R⁴ means alkenyl substituted with phenyl or pyridine; naphthyl, quinoxalinyl, quinolinyl, benzothiophenyl, dihydroxyphenyl or pyridyl substituted with acylamino-group; R² is C₁-C₆-alkyl that can be substituted with phenyl or pyridyl; R³ is groups -OR⁶ or -NHR⁶ where R⁶ means hydrogen atom, C₁-C₆-alkyl that can mean phenyl, pyridine or morpholinyl, to their tautomeric and isomeric forms and salts. Compounds of the formula (I) show inhibitory properties with respect to enzymes, in part, to cysteine proteases, for example, kalpain and can be used in medicine. EFFECT: new compounds indicated above, valuable biochemical properties. 3 cl, 2 tbl, 16 ex