COMPOSITION AND METHOD OF STABILIZATION OF BIOLOGICAL MATERIALS BY DRYING WITHOUT FREEZING Russian patent published in 2002 - IPC

Abstract RU 2191003 C2

FIELD: biology, biochemistry, medicine. SUBSTANCE: invention relates to dry partially amorphous products that comprise an active component and stabilizing mixtures of substances including at least two components. One substance of a stabilizing mixture is taken among a group comprising monosaccharides, disaccharides and zwitterion with a polar residue. The indicated zwitterion means arginine, aspartic acid, citrulline, glutamic acid, ornithine, histidine, lysine. The second substance of a stabilizing mixture is a zwitterion with a nonpolar residue and means acetylphenylalanine ester, alanine, cysteine, glycine, leucine, methionine, tryptophan, valine, sarcosine. Biologically active material means peptides, proteins, glycoproteins, antibodies, viruses, vaccines, cells and other substances. According to a method of preparing amorphous products the solution of biologically active component and indicated stabilizing substances are prepared and then solution is dried without its freezing. Stabilized biological materials show stability in storage at the room temperature and can be used for diagnosis and therapeutic aims. EFFECT: improved method of preparing. 20 cl, 3 dwg, 29 tbl

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RU 2 191 003 C2

Authors

Mattern Markus

Vinter Gerkhard

Dates

2002-10-20Published

1996-10-24Filed