DERIVATIVES OF DIALKYL ETHER, (PHARMACEUTICAL COMPOSITION) Russian patent published in 2002 - IPC

FIELD: Organic chemistry, medicine, pharmacy. SUBSTANCE: Invention describes novel derivatives of dialkyl ether of the general formula (1) given in the invention description where n and m mean independently each of other whole numbers from 2 to 6; R¹,R²,R³R⁴ mean independently each of other alkyl with carbon atom numbers from one to six; Y¹ and Y² mean independently each of other carboxyl group or group COOR⁵ where R⁵ means alkyl with carbon atom numbers from one to six. Indicated compounds are used in pharmaceutical composition eliciting activity with respect to decrease of plasma level of lipoprotein (a), apolipoprotein B, triglycerides, cholesterol complex with lipoproteins of low and very low density and with respect to increase of plasma level of apolipoprotein A-1 or E, cholesterol complex with lipoproteins of high density. Invention describes also method of decrease of plasma level of lipoprotein (a), apolipoprotein B, triglycerides, cholesterol complex with lipoproteins of low or very low density by administration effective dose of compound of the formula (1) as active substance and method of increase of plasma level of cholesterol complex with lipoproteins of high density or apolipoproteins A-1 and E by administration of effective dose of compound of the formula (1) as active substance. Invention describes also method of prophylaxis or treatment of disease of vessels and method of prophylaxis or treatment of insulin-nondependent diabetes mellitus by administration of compound of the general formula (1) as active substance. EFFECT: improved method of treatment and prophylaxis, valuable medicinal properties of compounds. 22 cl, 40 dwg, 12 ex