FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes form of 1-[2-(2-naphthyl)ethyl] -4-(3-trifluoro-methylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride as microparticles consisting of particles 55% of that have diameter less 50 mcm and showing broad peak of differential scanning calorimetry from 145 C to 147.6 C. Invention describes also pharmaceutical composition useful for treatment of neurodegeneration and comprising said form as an active component. The use of microparticles makes possible to decrease the dose of drug in pharmaceutical composition and provides homogeneous absorption in oral administration. EFFECT: improved properties of form. 12 cl
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Year |
Author |
Number |
| METHOD OF CRYSTALLIZATION OF 1-[2-(2-NAPHTHYL)-ETHYL]-4-(3- TRIFLUOROMETHYLPHENYL)-1,2,3,6-TETRA-HYDROPYRIDINE HYDROCHLORIDE, PREPARED CRYSTALLINE FORMS AND PHARMACEUTICAL COMPOSITION |
1997 |
- Karon Antuan
- Frank Brjuno
- Monn'E Oliv'E
|
RU2192416C2 |
| DIPHENYLALKYLTETRAHYDROPYRIDINES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF |
1997 |
- Baroni Marko
- Kardamone Rozanna
- Furn'E Zhaklin
- Gutstsi Umberto
|
RU2198874C2 |
| 1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1997 |
- Baroni Marko
- Kardamone Rozanna
- Furn'E Zhaklin
- Gutstsi Umberto
|
RU2189975C2 |
| AMINES FOR PREPARING MEDICINAL AGENTS DESIGNATED FOR PROPHYLAXIS OF TUMOR CELLS PROLIFERATION |
1997 |
- Brel'Er Zhan-Klod
- Ferrara Paskual'
- Lebuteje Kristin
- Pol' Rajmon
- Rozenfel'D Khorkhe
- Van Bruk Did'E
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RU2176502C2 |
| PHARMACEUTICAL COMPOSITION FOR ORAL USE OF DERIVATIVE OF N-PIPERIDINE-3-PYRAZOLE CARBOXYLIC ACID AMIDE, ITS SALTS AND THEIR SOLVATES |
1998 |
- Abramovichi Bernar
- Kondamin Kristian
- Gromenil' Zhan-Klod
|
RU2193886C2 |
| 4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS |
1996 |
- Domeniko Badone
- Marko Baroni
- Rozanna Kardamone
- Zhaklin Furn'E
- Umberto Gudzi
- Alessandra Elmini
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RU2163237C2 |
| PHARMACEUTICAL MICROSPHERICAL VALPROIC ACID PARTICLE FOR ORAL ADMINISTRATION |
1997 |
- Langlua Kristian
- Lann Zhan-Iv
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RU2177315C2 |
| PHARMACEUTICAL COMPOSITIONS CONTAINING DERIVATIVES OF N-SULFONYLINDOLINE |
1997 |
- Got'E Zhan-Klod
- Faller Sajmon Dzhon
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RU2174394C2 |
| NOVEL PENTASACCHARIDES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF |
1999 |
|
RU2193040C2 |
| APPLICATION OF COMPOUND-AGONISTS OF HUMAN CB RECEPTOR FOR PREPARING MEDICINAL IMMUNOMODULATING AGENTS, NOVEL COMPOUNDS-AGONISTS OF CB RECEPTOR AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF |
1996 |
- Rinal'Di Mjuriel'
- Bart Fransis
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- Kon'I Kristian
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- Bell Mal'Kol'M R.
- D'Ambra Tomas E.
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RU2200736C2 |
