PHARMACEUTICAL COMPOSITIONS CONTAINING DERIVATIVES OF N-SULFONYLINDOLINE Russian patent published in 2001 - IPC

Abstract RU 2174394 C2

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to compositions designated for parenteral or oral administration. Compositions have derivative of N-sulfonylindole of the formula (I): . These compounds can be used for treatment of patients with disorders of the central nervous system. Invention claims dissolving and stabilizing systems that are emulsified or microemulsified in water and designated for compound (I). System has one or some nonionic hydrophilic compounds exhibiting surface-active and amphiphilic properties simultaneously or it can contain a mixture consisting of, at least, one amphiphilic compound and nonionic hydrophilic surface-active substance. Pharmaceutical composition has the compound (I), claimed dissolving and stabilizing systems and, if necessary, pharmaceutically acceptable excipient or carrier. Composition can be emulsified or microemulsified in an aqueous medium. Invention claims soft pharmaceutical capsule containing the above indicated composition designated for oral administration. Invention proposes gelatin capsule for oral administration containing the claimed composition. Invention ensures to design anhydrous pharmaceutical compositions with high concentration of hydrophobic active substance. Composition can be made as tablets or capsules. Capsules have an active component in dissolved form owing to solubilizing/stabilizing system. EFFECT: improved properties of compositions. 29 cl, 3 dwg, 10 tbl, 56 ex

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RU 2 174 394 C2

Authors

Got'E Zhan-Klod

Faller Sajmon Dzhon

Dates

2001-10-10Published

1997-12-04Filed