FIELD: chemical-pharmaceutical industry, organic chemistry, chemical technology. SUBSTANCE: invention relates to synthesis of benzhydryl chloride that is a semifinished article used in synthesis of medicinal preparations cinnarizine, cetirizine, hydroxyzine. Benzhydryl chloride of the formula 
where X means H or Cl is synthesized by interaction of benzhydrols of the formula 
where X has the above given values with concentrated hydrochloric acid in the mole ratio corresponding benzhydrol : hydrochloric acid = 1 : (2.5-8), respectively, in the presence of water-soluble organic solvent, in part, acetone or dioxane being acetone or dioxane are used in the amount 1-2 vol. p. per 1 weight p. of corresponding benzhydrol. EFFECT: increased yield and enhanced purity of end compound. 2 cl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF SYNTHESIS OF 1-(PARA-CHLOROBENZHYDRYL)-4-(2-HYDROXYETHYL)-PIPERAZINE | 2001 |
|
RU2204556C2 |
| METHOD OF ISOLATION AND PURIFICATION OF (RR,SS)-2-[(DIMETHYLAMINO)METHYL]-1-(3-METHOXYPHENYL)-CYCLOHEXANOL (TRAMADOL) HYDROCHLORIDE | 2001 |
|
RU2196765C2 |
| METHOD OF SYNTHESIS OF BENZHYDROL β-DIMETHYLAMINOETHYL ESTER HYDROCHLORIDE | 1992 |
|
RU2036899C1 |
| METHOD OF SYNTHESIS OF META-HALOIDPHENOLS | 2000 |
|
RU2177932C1 |
| METHOD OF SYNTHESIS OF 5-AMINOSALICYLIC ACID FOR PHARMACEUTICAL AIMS | 1998 |
|
RU2155746C2 |
| METHOD OF OBTAINING N-METHYL-3-PHENYL-3-(4-TRIFLUORINEMETHYLPHENOXY)- PROPYLAMIN HYDROCHLORIDE | 2007 |
|
RU2336264C1 |
| METHOD OF OBTAINING HYDROCHLORIDE 2-PHENYLTHIOMETHYL-3- CARBOTOXY-4-DIMETHYLAMINOMETHYL-5-OXYBENZOFURAN | 1979 |
|
SU826707A1 |
| METHOD OF SYNTHESIS OF (Z)-1-[4-(2-DIMETHYLAMINOETHOXY)PHENYL]-1,2- DIPHENYLBUT-1-EN | 1989 |
|
SU1617890A1 |
| GRANULATED HEXOGEN PREPARATION METHOD | 1999 |
|
RU2211822C2 |
| METHOD FOR PREPARING HEXAMETHYLENEDIAMINE TETRAACETATE DICOPPER (II) | 2003 |
|
RU2243965C1 |
