DERIVATIVES OF ISOXAZOLE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of isoxazole of the formula (1) where D means hydrogen atom; one of A and B means group (1) -E-N= C(NR²⁵R²⁶)NR²⁷R²⁸ where E means a single bond or alkylene group; R²⁵ and R²⁶ each means independently hydrogen atom, C_1-4-alkyl, -(CH₂)_n-CO₂R³² where n is a whole number 1-3; R³² means hydrogen atom, C_1-4-alkyl, -(CH₂)_m-CO₂R³⁵ where m = 2 or 3; R³⁵ means hydrogen atom, C_1-4-alkyl, -(CH₂)_m where m is given above or -(CH₂)_n-C(O)R³⁶ where n is given above; R³⁶ means hydrogen atom, C_1-4-alkyl and so on; or taken in common they form with nitrogen atom 5-7-membered saturated nitrogen-containing heterocyclic group that can be substituted with one or two substituted taken among alkyl group, hydroxyl group and oxo-group; R²⁷ and R²⁸ each means independently hydrogen atom, -(CO)O-R³² where R³² means C_1-4-alkyl; or R²⁶ and R²⁷ form with two nitrogen atoms and one carbon atom 5-7-membered saturated nitrogen-containing heterocyclic group that can be substituted with one or two substitutes taken among alkyl group, -(CH₂)_m-; R²⁵ and R²⁶ mean independently hydrogen atom, C_1-3-alkyl or -(CH₂)_m-OH-OH and so on; (2) -E-N(R⁴⁵)C(NR⁴⁶R⁴⁷)=NR⁴⁸ where R⁴⁵ means hydrogen atom, C_1-4-alkyl, -(CO)O-R³²; R⁴⁸ means hydrogen atom, benzyl group and so on; and R⁴⁷ each means hydrogen atom, C_1-4-alkyl, -(CO)O-R³²; or taken in common they form with nitrogen atom 5-7-membered saturated nitrogen-containing heterocyclic group and so on; one of A and B means group of the formula -J-G where G means phenyl, biphenyl, benzoylphenyl and so on; J means -C(R⁸R⁹)- or -C(=CR⁸R⁹)-, where R⁸ and R⁹ mean independently hydrogen atom, lower alkoxy-group, lower alkyl group and so on; or their pharmaceutically acceptable salts. Invention relates also to pharmaceutical composition used for treatment of autoimmune diseases or inflammatory diseases and comprising derivative of isoxazole of the formula (1) or its pharmaceutically acceptable salt as active component in common with pharmaceutically acceptable carrier. Invention relates also to method of treatment of autoimmune diseases or inflammatory diseases involving administration of derivative of isoxazole of the formula (1) or its pharmaceutically acceptable salt in effective amount in human body. EFFECT: new isoxazole derivatives, valuable medicinal properties of compounds. 12 cl, 1 dwg, 4 tbl