NOVEL IMINO-DERIVATIVES AS INHIBITORS OF BONE RESORPTION AND ANTAGONISTS OF VITRONECTIN RECEPTOR Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to compounds of the formula: R¹-Y-A-B-D-E-F-G where A means ; B means -alkanediyl; D means O-, ; E means 6-membered aromatic ring system; F means values given for D; G means R¹; Y means a single bond; R² means 4-10-membered mono- or polycyclic aromatic or nonaromatic ring system that, if necessary, can involve 1-4 nitrogen atoms; R⁸OR⁹ means hydrogen atom; R⁴, R⁵, R⁶, R⁷ mean independently each of other hydrogen atom, R⁸N(R²)R⁹, R⁸OC(O)N(R²)R⁹; R⁸ means hydrogen atom or (C₅-C₁₄)-aryl-(C₁-C₈)-alkanediyl; R⁹ means a single bond; R¹⁰ means C(O)R¹¹; R¹¹ means OH; p and q = 0 or 1 being independently each of other in all their stereoisomeric forms and their mixtures in all ratios. Compounds are good antagonists of vitronectin receptor and inhibitors of bone resorption. Invention proposes also method of synthesis of compounds and pharmaceutical composition. EFFECT: improved method of synthesis, valuable medicinal properties of compounds. 8 cl, 1 ex