GUANIDINEALKYL-1,1-BIS- PHOSPHONIC ACID DERIVATIVES, AND METHOD OF PREPARING THEREOF Russian patent published in 1998 - IPC

FIELD: medicine, more particularly prevention of bone resorption. SUBSTANCE: present invention describes guanidine alkyl-1,1-bis- phosphonic acid derivatives of formula (I): R¹¹ and R¹²-R¹³SO₂,R¹⁴R¹⁵N- and tautomeric forms thereof wherein R is (a) disubstituted phenyl with substituents R¹³,R¹⁴,R¹⁵ such as pyridinyl, phenoxy, halogen; C₁-C₆ are R⁵-R⁸-alkyl; (b) N-substituted indolyl; C₁-C₆ is hydrogen or R⁵-R⁸-alkyl. Reagent 1: compound of formula (II): in which are as defined above. Reagent 2: compound of formula (III): . Reaction conditions: in inert solvent. EFFECT: improved properties of the title compounds. 5 cl, 11 ex, 1 tbl