DERIVATIVES OF 5H-THIAZOL[3,2-A]PYRIMIDINE, INTERMEDIATE COMPOUNDS AND MEDICINAL AGENT Russian patent published in 2003 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of 5H- thiazol[3,2-a]pyrimidine of the general formula (I) where R¹ means (lower) alkyl or benzyl; R² means (lower) alkyl, (lower) alkoxy-group, -O(CH₂)_nN(R¹³)(R¹⁴) or -N(R¹⁵)(CH₂)_nN(R¹³)(R¹⁴); each of R³-R¹⁴ means hydrogen, halogen atom, (lower) alkyl, (lower) alkoxy-group or benzylhydroxy-group; or R⁶ and R⁷ form in common benzene ring; each of R¹³-R¹⁵ means hydrogen atom or (lower) alkyl; n = 1-3, and pharmaceutically acceptable salts. Invention relates also to derivatives of thioxopyrimidine of the general formula (II) R¹-R⁷ as intermediate compounds where values are given above. Invention relates also to medicinal agent eliciting effect of antagonist of metabotropic glutamate receptors comprising compound of the formula (I) and therapeutically inert carrier. Invention provides synthesis of new compounds showing effect of antagonist of metabotropic glutamate receptors. EFFECT: valuable medicinal properties of compounds. 8 cl, 30 ex