BENZENESULFONE DERIVATIVES AND MEDICINAL AGENT Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to benzenesulfone derivatives of the formula (I) where R¹ means hydrogen atom; R² means hydrogen atom, trifluoromethyl group or (lower) alkyl; R³ means hydrogen atom or amino-group; or R¹ and R² or R³ and R² in common form the group -CH=CH-CH=CH-; Z means pyrimidine-4-yl, pyridine-4-yl, pyridine-2-yl or phenyl; R⁴ and R⁵ each means independently hydrogen atom, (lower) alkyl, trifluoromethyl group, halogen atom, (lower) alkoxyl-group, nitrile, amino-group, (lower) alkylamino-group, di-(lower) alkylamino-group, piperazinyl, morpholinyl, pyrrolidinyl, vinyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, tert. -butylethynyl, hydroxyalkylethynyl, phenylethynyl, naphthyl, thiophenyl or phenyl that can be substituted with halogen atom, (lower) alkoxyl-group, (lower) alkyl, trifluoromethyl group or nitro-group, or group , -morpholine-4-yl or ; n=2-4; R⁶ and R⁷ each means independently each of other hydrogen atom or (lower) alkyl, and their pharmaceutically acceptable salts. Invention describes also a medicinal agent based on the claimed compounds that elicit selective affinity to 5-HT-6 receptors. They are useful for treatment and prophylaxis of the central nervous system disturbances. EFFECT: valuable medicinal properties of compounds. 11 cl, 1 tbl