2,4-DIOXO-5-ARYLIDENEIMINO-1,3-PYRIMIDINES Russian patent published in 2003 - IPC

FIELD: organic chemistry, heterocyclic compounds, pharmacy. SUBSTANCE: invention relates to novel 2,4-dioxo-5-arylideneimino-1,3-pyrimidines of the general formula (I) where R is taken independently among group: H, OH, lower alkoxyl-group, halogen atom, nitro-group, di-(lower)-alkylamino-group; n = 1-3; or two adjacent R in common with benzene ring to which they are bound form benzo-, dibenzo-group at n = 2, 4 and they form 3,4-dioxolane ring at n = 2. The most preferable are compounds of the general formula (I) where R is H; n = 1; or R is 4-Cl; n = 1; or R is 3-Cl; n = 1; or R is 2-Cl; n = 1; or R is 4-Br; n = 1; or R is 4-OH; n = 1; or R is 2,4-(OH)₂; n = 2; or R is 2-OH; 5-Br; n = 2; or R is 2-OH; 5-Cl; n = 2; or R is 4-F; n = 1; or R is 2,4-Cl₂; n = 2; or R is 2-OH; 3,5-Cl₂; n = 3; or R is 2-OH; 3,5-Br₂; n = 3; or R is 4-OCH₃; n = 1; or R is 4-OH; 3-OCH₃; n = 2; or R is 4-NO₂; n = 1; or R is 3-NO₂; n = 1; or R is 2-NO₂; n = 1; or R is 2-OH, 5-NO₂; n = 2; or R is 2-OH; 5,6-benzo-group; n = 3; or R is 3,4-dioxolano-group; n = 2; or R is 2-NO₂; 4,5-dioxolano-group; n = 3; or R is 2,3,5,6-dibenzo-group; n = 4; or R is 2-OH, 3,5-J₂; n = 3; or R is 4-N(CH₃)₂; n = 2. Indicated compounds show antiviral, immunostimulating, antichlamidiosis, antituberculosis, psychodepressive, analgetic and hepatoprotective effects and can be used in pharmaceutical industry. EFFECT: valuable medicinal properties of compounds. 26 cl, 10 tbl, 1 ex