SUBSTANCE WITH ANTIVIRAL AND ANTIBACTERIAL ACTIVITY BASED ON DERIVATIVES OF 2,8-DITHIOXO-1H-PYRANO[2,3-D; 6,5-D']DIPYRIMIDINE AND THEIR 10-AZA-ANALOGUES Russian patent published in 2005 - IPC

Abstract RU 2246496 C1

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to a new substance eliciting an antiviral and antibacterial activity that is based on derivatives of 2,8-dithioxo-1H-pyrano[2,3-d;6,5-d']dipyrimidine and their 10-aza-analogues. This substance comprises derivative of indicated group of the general formula: A1*M: wherein X is taken among the group: oxygen atom (O), NH, N-alkyl; R1 is taken among the group: hydrogen atom (H), OH, chlorine atom (Cl), O-alkyl, NH₂, NH-alkyl, NH-Ar, N-(alkyl)₂, SH, S-alkyl; R2 is taken among the group: unsubstituted or substituted phenyl, naphthyl, thienyl; R3 is taken among the group: hydrogen atom (H), chlorine atom (Cl), O-alkyl, NH₂, NH-alkyl, S-dihydroxypyrimidinyl; M is absent or taken among the group: cation Na, K, Li, ammonium or any other pharmacologically acceptable cation; or complex of pharmacologically acceptable cation (see above) with anion of one of derivatives of A1 (variants R1-R3 are given above). Invention provides preparing new compounds eliciting an antiviral and antibacterial activity.

EFFECT: valuable medicinal properties of substance.

17 cl, 7 tbl, 16 ex

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RU 2 246 496 C1

Authors

Tets V.V.

Krasnov K.A.

Ashkinazi R.I.

Dates

2005-02-20—Published

2003-09-12—Filed