IMPROVED COPOLYMER-1 AND METHOD OF PREPARATION THEREOF Russian patent published in 2003 - IPC

Abstract RU 2198900 C2

FIELD: polymer production. SUBSTANCE: invention provides method for preparation of copolymer- 1 representing mixture of polypeptides constituted by alanine, glutamic acid, lysine, and tyrosine at molar ratio approximately 6:2:5:1 and having molecular weight about 5 to 9 kDa, which consists in reaction of protected copolymer-1 with hydrobromic acid to form trifluoroacetyl-copolymer-1 and treatment of the latter with aqueous solution of piperidine to give copolymer-1, which, after purification, has required molecular weight. Copolymer-1 is used for treatment of disseminated sclerosis. EFFECT: improved preparation procedure. 6 cl, 2 dwg, 1 tbl, 4 ex

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RU 2 198 900 C2

Authors

Konfajno Ehlizer

Sela Majkl

Tajtel'Baum Dvora

Arnon Rut

Dates

2003-02-20Published

1995-05-23Filed