STYRYLSULFONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF, METHOD OF INHIBITION OF TUMOR CELL GROWTH, METHOD OF TUMOR CELL APOPTOSIS INDUCTION AND TREATMENT METHOD Russian patent published in 2003 - IPC

Abstract RU 2201919 C2

FIELD: organic chemistry, medicine, oncology, pharmacy. SUBSTANCE: invention relates to styrylsulfone compounds of the formula (I) where n = 0 or 1; R1 is taken among group including chlorine, fluorine or bromine atom; R2 is taken among group including chlorine, fluorine and bromine atom; R3 is taken among group including hydrogen and fluorine atom; both radicals R1 and R2 can not mean chlorine atom in the case when R3 represents hydrogen atom; R1 can not mean chlorine atom in the case when R2 represents fluorine atom; R3 represents hydrogen atom in the same compound. Invention describes also pharmaceutical compositions of formulas (II) , (III) and (IV) . Styrylsulfone compounds relating to the present invention inhibit proliferation of breast and prostate tumor cells and induce apoptosis of such tumor cell being without effect on normal cells. EFFECT: enhanced effectiveness of inhibition and apoptosis induction of tumor cells, improved method of treatment. 42 cl, 9 dwg, 5 tbl, 33 ex

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RU 2 201 919 C2

Authors

Reddi Premkumar Eh.

Reddi Ramana M.V.

Dates

2003-04-10Published

1998-10-01Filed