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(19)

(11)

2 708 032

(13)

(51)

IPC

C07K16/28(2006-01-01)

C07K19/00(2006-01-01)

A61K35/17(2015-01-01)

A61K39/44(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

C12N5/10(2006-01-01)

A61P35/00(2006-01-01)

C12N5/783(2010-01-01)

(21) (22)

Application

2015139874, 2014-02-20

(24)

Start date

2014-02-20

(22)

Actual filing date

2014-02-20

(45)

Published

2019-12-03

(72)

Inventor

Brogdon DzhenniferDzhonson Laura AleksandraDzhun Karl Kh.Lev AndreasMaus MarselaSholler DzhonOkada Khidekho

(73)

Holder

Novartis AgDze Trastiz Of Dze Yuniversiti Of PensilvaniyaYuniversiti Of Pittsburg Of Dze Kommonvelt Sistem Of Khajer Edyukejshn

CANCER TREATMENT USING CHIMERIC ANTIGEN-SPECIFIC RECEPTOR BASED ON HUMANISED ANTI-EGFRvIII ANTIBODY Russian patent published in 2019 - IPC C07K16/28 C07K19/00 A61K35/17 A61K39/44 C12N15/13 C12N15/63 C12N5/10 A61P35/00 C12N5/783

Abstract RU 2708032 C2

FIELD: medicine.

SUBSTANCE: present invention relates to immunology. Disclosed is a binding domain against EGFRvIII, comprising a chimeric antigenic receptor encoding nucleic acids, a vector, a cell, as well as use of said inventions in the manufacture of a medicament, methods of producing a cell and obtaining a population of cells, a method for providing immunity, a method of treating.

EFFECT: present invention can find further application in therapy using adaptive cell transfer.

103 cl, 18 dwg, 9 ex, 2 tbl

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RU 2 708 032 C2

Authors

Brogdon Dzhennifer

Dzhonson Laura Aleksandra

Dzhun Karl Kh.

Lev Andreas

Maus Marsela

Sholler Dzhon

Okada Khidekho

Dates

2019-12-03—Published

2014-02-20—Filed