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2 202 365

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IPC

(21) (22)

Application

2001120083/14, 2001-07-20

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Start date

2001-07-20

(22)

Actual filing date

2001-07-20

(45)

Published

2003-04-20

(72)

Inventor

Bairamashvili D.I.Karateeva R.I.Sizova N.V.Govorukhina E.I.Davydov V.L.Miroshnikov A.I.

(73)

Holder

Institut Bioorganicheskoj Khimii Im. M.M.Shemjakina I Ju.A.Ovchinnikova Ran

METHOD FOR PREPARING QUICK ACTION INSULIN SOLUTION FOR MAKING INJECTIONS Russian patent published in 2003 - IPC

Abstract RU 2202365 C2

FIELD: medicine. SUBSTANCE: method involves solving human insulin substance of activity equal to at least 27.5 ED/mg is solved in acid aqueous medium in zinc ions presence until their total concentration in the preparation reaches 25-30 mcg per 100 ED of insulin. Then inhibitor solution produced by dissolving Nypagin in water for injections at room temperature and pH 9.0-11.0 is added under constant stirring. Then, solution of trihydrate of sodium acetate and glycerol is added, solution pH is adjusted to 7.3-7.5 and sterilizing filtration is carried out. The produced solution is hold during 15-20 days at 2-8 C and repeatedly filtered. EFFECT: highly effective stable preparation. 1 tbl

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RU 2 202 365 C2

Authors

Bairamashvili D.I.

Karateeva R.I.

Sizova N.V.

Govorukhina E.I.

Davydov V.L.

Miroshnikov A.I.

Dates

2003-04-20—Published

2001-07-20—Filed