METHOD OF PREPARING PHARMACEUTICAL COMPOSITION SOLUTION BASED ON SUBSTANCE OF GENE ENGINEERING (RECOMBINANT) HUMAN INSULIN Russian patent published in 2002 - IPC

Abstract RU 2184533 C1

FIELD: medicine, endocrinology, pharmacy. SUBSTANCE: invention relates to treatment of patients with diabetes mellitus with the preparation of rapid effect - the solution of domestic gene engineering (recombinant) human insulin prepared in cartridges and/or flasks. Preparation that is stable at storage is prepared by mixing solution containing a preserving agent m-cresol and sodium acetate with solution containing gene engineering human insulin, zinc chloride and glycerol. Sodium hydroxide solution is added to the prepared mixture to pH = 6.9-7.8, then sterilizing filtration is carried out, required volume is brought about and the preparation is placed into cartridges or flasks. Method provides safety of physical- chemical and biological properties of preparation at storage. EFFECT: improved method of preparing, expanded arsenal of antidiabetic agents. 3 cl, 2 tbl

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RU 2 184 533 C1

Authors

Khljabich G.N.

Pak M.F.

Pak T.V.

Bondareva L.N.

Mazov M.Ju.

Koldyshev A.E.

Dates

2002-07-10Published

2001-05-03Filed