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2 020 954

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IPC

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Application

5031054/14, 1992-02-24

(22)

Actual filing date

1992-02-24

(45)

Published

1994-10-15

(72)

Inventor

Avramenko L.G.Korostin V.I.Karateeva R.I.Donetskij I.A.Zalesskaja N.A.Novokhatskij A.S.Khljabich G.N.

(73)

Holder

Vserossijskij Nauchno-Issledovatel'Skij Institut Tekhnologii Krovezamenitelej I Gormonal'Nykh Preparatov

METHOD OF PREPARING OF INSULIN AQUEOUS SOLUTION Russian patent published in 1994 - IPC

Abstract RU 2020954 C1

FIELD: medicinal industry. SUBSTANCE: method involves successive performing of the following procedures: preparing solution 1 - 4.1-5.1 mg insulin is dissolved in 1 ml 0.05N acetic acid aqueous solution; preparing solution 2 - nipagin is dissolved in 0.1N sodium hydroxide solution (4.6-6.8 mg in solution). Then both solutions are mixed, glycerol and water are added up to required volume. Preparation is sterilized by filtration, kept at temperature 1-5 C for 14-30 days, and after repeated sterilizing filtration is poured into small bottles. EFFECT: increased stability of insulin aqueous solution to low temperature. 1 tbl

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RU 2 020 954 C1

Authors

Avramenko L.G.

Korostin V.I.

Karateeva R.I.

Donetskij I.A.

Zalesskaja N.A.

Novokhatskij A.S.

Khljabich G.N.

Dates

1994-10-15—Published

1992-02-24—Filed

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