FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to novel 1,8-annelated derivatives of 2-quinolinone of the formula (I) 
where A, X, R1, R2, R3, R4, R5, R6 are given in the invention claim. Invention describes also method of synthesis of proposed compounds, pharmaceutical composition exhibiting inhibitory effect on farnesyl- transferase activity and method for its preparing. Invention discloses intermediate compounds useful for synthesis of proposed compounds and method of their synthesis also. Invention can be used in medicine as therapeutic agent. EFFECT: valuable medicinal properties. 11 cl, 7 tbl
| Title |
Year |
Author |
Number |
| QUINAZOLINONES INHIBITING FARNESYLTRANSFERASE ACTIVITY |
1998 |
- Anzhibo Patrik Rene
- Vene Mark Gaston
- Frehjn Ehddi Zhan Ehdgar
|
RU2205831C2 |
| MONOCYCLIC BENZAMIDES OF DERIVATIVES OF 3- OR 4-SUBSTITUTED 4-(AMINOMETHYL)PIPERIDINE, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION, METHOD FOR ITS PREPARING, DERIVATIVE OF CARBOXYLIC ACID |
1998 |
- Bosman Zhan-Pol' Rene Mari Andre
- De Klejn Mishel' Anna Jozef
- Sjurkin Mishel'
|
RU2213089C2 |
| TRICYCLIC ?3-PIPERIDINES, METHODS FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1999 |
- Kennis Ljudo Ehdmon Zhozefin
- Van Den Kejbus Frans Marija Al'Fons
- Mertens Jozefus Karolus
|
RU2230744C2 |
| DERIVATIVES OF THIADIAZOLYLPYRIDAZINE INHIBITING ANGIOGENESIS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING |
1998 |
- Stokbruks Rajmon Antuan
- Kester Mark Andre
- Van Der Aa Marsel' Jozef Marija
- Lijks Marsel' Gerebernus Marija
- Villems Mark
- Tuman Robert V.
|
RU2194049C2 |
| DERIVATIVES OF (IMIDAZOL-5-YL)METHYL-2-QUINOLINONE AS INHIBITORS OF SMOOTH MUSCLE CELLS PROLIFERATION |
1998 |
- Ehnd Devid Vill'Jam
- Zelesko Majkl Dzh.
|
RU2209066C2 |
| BENZOTHIENO[3,2-C]PYRIDINES, METHOD FOR THEIR PREPARING (VARIANTS), PHARMACEUTICAL COMPOSITION AND METHOD FOR ITS PREPARING |
1999 |
- Kennis Ljudo Ehdmon Zhozefin
- Piters Serzh Marija Aloisius
- Bishoff Fransua Pol'
|
RU2222542C2 |
| DERIVATIVES OF 5-SUBSTITUTED 1,2,4-THIADIAZOLYL, METHOD OF THEIR SYNTHESIS (VERSIONS), PHARMACEUTICAL COMPOSITION, INTERMEDIATE COMPOUND AND METHOD OF ITS SYNTHESIS |
1998 |
- Stokbruks Rajmon Antuan
- Kester Mark Andre
- Van Der Aa Marsel' Jozef Marija
- Lijks Marsel' Gerebermus Marija
- Villems Mark
- Tuman Robert V.
|
RU2199538C2 |
| TETRAHYDRO-GAMMA-CARBOLINES AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1998 |
- Kennis Ljudo Ehdmond Zhozefin
- Mertens Zhozefus Karolus
|
RU2208614C2 |
| DERIVATIVES OF BENZYLBIPHENYL, METHOD FOR THEIR PREPARING, BIOCIDE COMPOSITION, METHOD FOR ITS PREPARING AND METHOD FOR CONTROL OF MICROORGANISMS |
1999 |
- Merpul Liven
- Van Der Flas Mark Artur Josefa
- Van Der Veken Lui Jozef Ehlizabet
- Kheres Jan
|
RU2218333C2 |
| PYRIDINE DERIVATIVES USED AS QUICKLY DISSOCIABLE DOPAMINE RECEPTOR 2 ANTAGONISTS |
2008 |
- Makdonal'D Gregor Dzhejms
- Bartolome-Nebreda Khose Manuehl'
- Van Gol Mikhil' Ljuk Marija
- Del'Gado-Khimenes Fransiska
|
RU2480462C2 |
