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2 480 462

(13)

(51)

IPC

C07D401/12(2006-01-01)

A61K31/44(2006-01-01)

A61P25/18(2006-01-01)

(21) (22)

Application

2009142988/04, 2008-04-18

(24)

Start date

2008-04-18

(22)

Actual filing date

2008-04-18

(45)

Published

2013-04-27

(72)

Inventor

Makdonal'D Gregor DzhejmsBartolome-Nebreda Khose Manuehl'Van Gol Mikhil' Ljuk MarijaDel'Gado-Khimenes Fransiska

(73)

Holder

Janssen Farmatsevtika N.V.

PYRIDINE DERIVATIVES USED AS QUICKLY DISSOCIABLE DOPAMINE RECEPTOR 2 ANTAGONISTS Russian patent published in 2013 - IPC C07D401/12 A61K31/44 A61P25/18

Abstract RU 2480462 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to novel compounds specified in [1-(3,4-difluorobenzyl)-piperidin-4-yl]-(5-trifluoromethylpyridin-2-yl)amine, 6-{methyl-[1-(3-trifluoromethylbenzyl)-piperidin-4-yl]amino}nicotinonitrile, 6-[1-(3-trifluoromethylbenzyl)-piperidin-4-ylamino]nicotinonitrile, 6-[1-(3-fluoro-5-trifluoromethylbenzyl)-piperidin-4-ylamino]nicotinonitrile, 6-[1-(3,5-difluorobenzyl)-piperidin-4-ylamino]nicotinonitrile, 6-[1-(3,4,5-trifluorobenzyl)-piperidin-4-ylamino]nicotinonitrile, 2-{methyl-[1-(3-trifluoromethylbenzyl)piperidin-4-yl]amino}isonicotinonitrile, 6-[1-(3-fluoro-5-trifluoromethylbenzyl)piperidin-4-ylamino]pyridin-2-carbonitrile, (1-benzyl-piperidin-4-yl)-(5-trifluoromethylpyridin-2-yl)amine, 6-[1-(3,5-difluorobenzyl)piperidin-4-ylamino]-pyridin-2-carbonitrile; 6-[1-(3,4,5-trifluorobenzyl)piperidin-4-ylamino]-pyridin-2-carbonitrile and 6-(1-benzyl-piperidin-4-ylamino)-pyridin-2-carbonitrile, to their pharmaceutically acceptable salts and stereoisomer forms used as antipsychotic agents, as well as to a based pharmaceutical composition.

EFFECT: preparing the compounds used as antipsychotic agents.

3 cl, 11 ex

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RU 2 480 462 C2

Authors

Makdonal'D Gregor Dzhejms

Bartolome-Nebreda Khose Manuehl'

Van Gol Mikhil' Ljuk Marija

Del'Gado-Khimenes Fransiska

Dates

2013-04-27—Published

2008-04-18—Filed