SUBSTITUTED BICYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INHIBITION Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) where a single dotted line means double linkage, double dotted line means a single linkage; n = 0; Q means compound of the formula (II) ; n1, n2 = 0-1; Q means substituted aryl or substituted heteroaryl; R¹, R² mean hydrogen atom, alkyl, fluoroalkyl, difluoroalkyl, alkenyl or they form in common group =O; R³ means hydrogen atom, hydroxy-group, alkoxy-group, alkyl, halogen atom, arylalkyl, hydroxyalkyl; Het means mono-, bi- or tricyclic heteroaromatic group; R⁸, R¹⁰, R¹¹ are taken among group including R¹, OR¹,; R⁹ means hydrogen atom, hydroxy-group, alkoxy-group or halogen atom; B means , cis- or trans- ; X means +O-, NR⁶; Y means =O, (H, H), (H, OH), (H). The above indicated compounds show antagonistic activity with regards to thrombin receptors and therefore they can be used as active substance in pharmaceutical composition in method for inhibition of thrombin receptors. EFFECT: improved method of inhibition, valuable medicinal properties of compounds. 12 cl, 4 tbl, 5 sch, 24 ex