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RU

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2 411 241

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IPC

C07D401/14(2006-01-01)

C07D401/06(2006-01-01)

A61K31/496(2006-01-01)

A61P31/18(2006-01-01)

(21) (22)

Application

2007135126/04, 2006-02-21

(24)

Start date

2006-02-21

(22)

Actual filing date

2006-02-21

(45)

Published

2011-02-10

(72)

Inventor

Chan Tze-MingKoks KehtlinFeng VenkingMiller Majkl V.Uehston DehniehlMakkombi Stjuart V.

(73)

Holder

Shering Korporejshn

PIPERIDINYLPIPERAZINE DERIVATIVES APPLICABLE AS CHEMOKINE RECEPTOR INHIBITORS Russian patent published in 2011 - IPC C07D401/14 C07D401/06 A61K31/496 A61P31/18 

Abstract RU 2411241 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds described by a structural formula wherein: R1 is chosen from a group including R9-phenyl, and R2 is chosen from a group including H and (C1-C6)-alkyl; R3 is chosen from a group including (C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-alkyl- and R9-(C6-C10)-aryl; R4, R5, R6 and R7 are independently chosen from a group including H and (C1-C6)-alkyl; R8 is chosen from a group including и ; R9 means 1, 2 or 3 substitutes independently chosen from a group, including H, halogen and -CF3; R10 is chosen from a group including H and (C1-C6)-alkyl; R11 is (C3-C10)-cycloalkyl-S (O2)-; R15 and R16 are independently (C1-C6)-alkyl; R17 is R20O-; R20 is chosen from a group including H, and (C1-C6)-alkyl-(C6-C10)-aryl; Q is N; Z is CH; n is equal to 0; s is equal to 2; and t is equal to 2. Also, the invention concerns a pharmaceutical composition exhibiting properties of a chemokine receptor inhibitor, based on these compounds.

EFFECT: produced are the new compounds and based pharmaceutical composition can find application in medicine for treating human immunodeficiency virus (HIV) infection.

8 cl, 2 tbl, 1 ex

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RU 2 411 241 C2

Authors

Chan Tze-Ming

Koks Kehtlin

Feng Venking

Miller Majkl V.

Uehston Dehniehl

Makkombi Stjuart V.

Dates

2011-02-10—Published

2006-02-21—Filed

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