FIELD: medicine, therapy, biochemistry, pharmacy. SUBSTANCE: invention relates to pharmaceutical composition used for administration into vertebral epidural space and comprising glycosaminoglycan- cleaving enzyme and a pharmaceutical carrier. Invention relates also to usage of enzyme cleaving glycosaminoglycans as a medicinal preparation used for therapy of hernia of intervertebral disk that is characterized by the presence of gelatinous core in epidural space where indicated preparation is administrated into vertebral epidural space. Invention can be used for therapy of hernia of intervertebral disk. EFFECT: enhanced effectiveness of therapy of hernia of intervertebral disk. 13 cl, 1 tbl, 1 dwg, 2 ex
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