METHOD FOR PREPARING 1-SUBSTITUTED 3,3-DIMETHYL-3,4- DIHYDROISOQUINOLINES Russian patent published in 2003 - IPC

Abstract RU 2213735 C2

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method for preparing 1-substituted 3,3-dimethyl-3,4-dihydroisoquinolines of the formula (I) wherein R is OMe; Me; X is Me; SMe; Ph; CH₂COOEt; CH₂CONH₂. Method involves addition of isobutyric aldehyde, 1,2- or 1,4-dimethoxy- (or dimethyl)-substituted benzene and nitrile of the formula RCN (wherein R is Me; SMe; Ph; CH₂COOEt; CH₂CONH₂) to concentrated sulfuric acid medium in the mole ratio of reagents = 1 : 1 : 1, respectively. Method provides preparing some new compounds. EFFECT: improved preparing method, reduced cost, expanded raw base.

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RU 2 213 735 C2

Authors

Shkljaev Ju.V.

Glushkov V.A.

Nifontov Ju.V.

Dates

2003-10-10—Published

2001-09-24—Filed