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2 436 775

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(51)

IPC

C07D221/06(2006-01-01)

A61K31/473(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2010123742/04, 2010-06-10

(24)

Start date

2010-06-10

(22)

Actual filing date

2010-06-10

(45)

Published

2011-12-20

(72)

Inventor

Shul'Ts Ehl'Vira EhduardovnaPetrova Tat'Jana NikolaevnaTolstikova Tat'Jana GenrikhovnaDolgikh Margarita PetrovnaTolstikov Genrikh Aleksandrovich

(73)

Holder

Novosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)

NOVEL OPTICALLY ACTIVE 4-HYDROXY-2-AZA-9,10-ANTHRAQUINONES, HAVING ANTIINFLAMMATORY ACTIVITY, AND SYNTHESIS METHOD THEREOF Russian patent published in 2011 - IPC C07D221/06 A61K31/473 A61P29/00

Abstract RU 2436775 C1

FIELD: chemistry.

SUBSTANCE: invention relates to novel optically active 3-alkyl-4-hydroxy-2-aza-9,10-anthraquinones of formula (Ia-f): R=H, R¹=Me (la); R=H, R¹=Et (1b); R=H, R¹=i-Pr (Ic); R=R¹=Me (Id); R=Me, R¹=Et (1e); R=Me, R¹=i-Pr (If). The invention also relates to the method of obtaining compounds of formula (Ia-f).

EFFECT: novel low-toxicity optically active derivatives of 3-alkyl-4-hydroxy-2-aza-9,10-anthraquinone, having anti-inflammatory activity, are obtained.

2 cl, 3 tbl 8 ex

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RU 2 436 775 C1

Authors

Shul'Ts Ehl'Vira Ehduardovna

Petrova Tat'Jana Nikolaevna

Tolstikova Tat'Jana Genrikhovna

Dolgikh Margarita Petrovna

Tolstikov Genrikh Aleksandrovich

Dates

2011-12-20—Published

2010-06-10—Filed