METHOD FOR EVALUATING AGGREGATION PROPERTIES OF BLOOD PLATELETS Russian patent published in 2003 - IPC

FIELD: medicine. SUBSTANCE: method involves taking blood samples, separating plasma and preparing it for making analysis, making blood platelets aggregation induction with adenosine diphosphate and collagen, saving aggregatogram with blood platelets aggregation degree and speed values. Integral index of blood platelets aggregation (IIBPA, in conditional units) is calculated from formula: IIBPA=K₁+K₂+K₃+K₄+Z, where K₁ is the ratio of blood platelets aggregation degree in patient under examination under adenosine diphosphatemediated aggregation induction to the like value mean obtained from healthy people data; K₂ is the ratio of blood platelets aggregation speed in patient under examination under blood platelets adenosine diphosphate- mediated aggregation induction to the like value mean obtained from healthy people data; K₃ is the ratio of blood platelets aggregation degree in patient under examination under collagen-mediated aggregation induction to the like value mean obtained from healthy people data; K₄ is the ratio of blood platelets aggregation speed in patient under examination under collagen-mediated aggregation induction to the like value mean obtained from healthy people data. Qualitative properties of aggregatograms are expressed as quantitative parameter Z, where the case of Z=+2 is interpreted as the second blood platelets aggregation wave when adenosine diphosphatemediated aggregation induction takes place or no disaggregation phenomena is observed; the case of Z=-2 is interpreted as no blood platelets aggregation wave when collagen-mediated aggregation induction takes place; the case of Z=0 is interpreted as no qualitative pathological signs are available on aggregatogram. IIBPA value being within the limits of 1.6-5.5 units, blood platelets aggregation ability is evaluated as normal. The value being greater than 5.5, hyperlevel of blood platelets aggregation ability is evaluated to be the case. The value being less than 1.6, hypolevel of blood platelets aggregation ability is evaluated to be the case. EFFECT: high objectivity level; wide range of diagnostic applications. 2 cl, 1 tbl