METHOD FOR THROMBOCYTE AGGREGATION ACTIVITY DETERMINATION FOR PATIENTS WITH ACUTE CORONARY SYNDROME Russian patent published in 2017 - IPC G01N33/86 

FIELD: medicine.

SUBSTANCE: method for thrombocyte aggregation activity determination for patients with acute coronary syndrome, includes venous blood sampling, istabilization, addition of aggregation inductors, thrombocyte aggregation activity assessment by the impedance method with parallel determination of ADP release reaction dynamics by fluorescent aggregation, determination of the maximum thrombocyte aggregation amplitude; its difference is that a working collagen suspension is added to the final concentration in solution of 2 mcg/mL, an aggregatogram and a curve of ADP release are recorded, time of aggregatogram exit to the plateau of maximum impedance amplitude is determined as absence of significant aggregatogram fluctuations less than Ω1/30 sec, after which the ADP solution is added by the bolus method to the final concentration in solution of 10 mcM, an aggregatogram and a curve of ADP release are recorded up to the maximum impedance amplitude exit to the plateau, and the maximum amplitude of the curve, and the thrombocyte aggregation activity is concluded based on the maximum aggregation curve amplitude and the ADP curve amplitude.

EFFECT: increased accuracy of determination.

1 dwg, 1 tbl, 2 ex