METHODS AND COMPONENTS FOR INDUCTION OF TUMOR- -SPECIFIC CYTOTOXICITY Russian patent published in 2003 - IPC

Abstract RU 2214280 C2

FIELD: medicinal genetics, oncology. SUBSTANCE: invention relates to method for expression of heterologous sequence in tumor cell by insertion of gene into cell subjected for imprinting. Gene comprises regulatory sequence, for example, H19 with promoter P3 or P4 IGF-2 and others that is able to operate the expression of cytotoxic products. Genes can be used for treatment of different cancer, viral and autoimmune disease. Description of invention comprises data concerning the corresponding expression vectors and methods of treatment. EFFECT: expanded arsenal of agents in genetic therapy. 40 cl, 10 dwg, 10 ex

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RU 2 214 280 C2

Authors

Khokhberg Abrakham

Ajesh Sukhail

Dates

2003-10-20—Published

1998-10-04—Filed